Matriks Biotek
Metin Kutusu: DDW week 2009: the anti-TNF battle 

Response prediction and switching
Only approximately 60% of patients respond to TNF inhibition. Consequently, research is focusing on predictors of response (biomarkers, composite assessment tools etc). By 2012, the ability to predict response will be shaping the autoimmune market, driven by cost efficiency and applicable to both biologics and small molecule products.
Previous opinion has considered that the optimization of infliximab Remicade is key before switching, but a presentation by Waqqas Afif suggested otherwise. He found that assessing the infliximab level and status of human anti-chimeric antibodies (HACAs) was useful and impacted clinical management. While increasing the dose in patients with non-therapeutic infliximab Remicade levels may be more effective than switching to another anti-TNF agent, this strategy did not work in patients who had HACAs. Afif concluded that changing treatment based on clinical symptoms alone may lead to inappropriate management.
Datamonitor predicts that improvements in serum tests and biomarker assessment (e.g. using Prometheus IBD diagnostic assays to verify non-response) will be key in the next few years, and will drive therapy choice from about 2012 onwards.

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R&D

Q-ETA

Enzyme immunoassay for the quantitative determination of Etanercept (Enbrel®) in serum and plasma      

 

Etanercept specific monoclonal antibody based Enzyme immunoassay for the quantitative determination of etanercept (Enbrel®) in serum and plasma samples between the Cmin and Cmax range of concentrations as indicated.

The user-friendly Matriks Biotek Q-ETA is the first and only ELISA kit in the market for the quantitative determination of etanercept (Enbrel®) at uppermost specificity.

Sample volume: 20 μL                    Total Test Reaction Time: 160 min.

 

 

S-ATE

Enzyme immunoassay for the qualitative determination (screening) of antibodies to etanercept in serum and plasma

The Matriks Biotek Antibody to Etanercept ELISA Kit can be efficiently used for monitoring anti-Etanercept antibodies during therapy and offers the clinician a tool for decision on possible preventive measures such as possible addition of immunosuppressive drug to reduce anti-etanercept antibodies.

Sample volume: 10 μL                    Total Test Reaction Time: 140 min.

QS-INFLIXI

Enzyme immunoassay for the specific quantitative determination of Infliximab (Remicade®) in serum, plasma and other biological fluids

Sample volume: 10 μL                    Total Test Reaction Time: 75 min.

 

Matriks Biotek Infliximab ELISA is developed for specific measurement of Infliximab (Remicade®) in sera, plasma and other biological fluids by the advantage of using a site-directed monoclonal antibody specific for Infliximab (Remicade®) only. The user-friendly Matriks Biotek Specific Infliximab ELISA is the first and only ELISA kit for the quantitative determination of Infliximab (Remicade®) at uppermost specificity.

 

Q-INFLIXI

Enzyme immunoassay for the quantitative determination of infliximab (Remicade®) in serum and plasma

Sample volume: 10 μL                    Total Test Reaction Time: 55 min.

 

Q-ATI

Enzyme immunoassay for the qualitative and quantitative determination of specific antibodies to infliximab in human serum and plasma.

Sample volume: 10 μL                    Total Test Reaction Time: 140 min.

 

“USE YOUR DRUG EFFECTIVELY  AND SAFELY”

 

Follow-up your patient’s trough infliximab levels, dose response to infliximab with QS-INFLIXI and adjust dose when needed.

 

Check anti-infliximab antibodies in your patients sera with Q-ATI , escalate the dose  or  combine with (e.g.) methotrexate when needed.

 

Q-ADA

Enzyme immunoassay for the quantitative determination of free adalimumab (Humira®) in serum and plasma. Matriks Biotek adalimumab ELISA has been especially developed for the quantitative analysis of free adalimumab in serum and plasma samples.

Sample volume: 20 μL                    Total Test Reaction Time: 70 min.

 

S-ATA

Enzyme immunoassay for the qualitative determination (screening) of antibodies to adalimumab in serum and plasma.

Adalimumab (Humira®) was associated to the development of anti-Adalimumab antibodies, even some were reported to be neutralizing, in various percentages of patients during therapy with the drug Humira®. This might lead to severe complications. The Matriks Biotek Antibody to Adalimumab ELISA Kit can be efficiently used for monitoring anti-Adalimumab antibodies during therapy and offers the clinician a tool for decision on possible preventive measures such as possible addition of immunosuppressive drug to reduce anti-Adalimumab antibodies.

Sample volume: 10 μL                    Total Test Reaction Time: 140 min.

innovation for health & wellness

Matriks Biyoteknoloji Ltd., as a biotechnology company is committed to R&D and production of immune based molecules and tools for the life science community. We produce recombinant proteins, monoclonal antibodies to have a better understanding of human related diseases.

 

The use of humanized recombinant monoclonal antibodies in certain diseases as biopharmaceuticals arouse the question of effectiveness in each individual treated person. We offer specific ELISA kits for the quantitative determination anti-TNF antibodies and blockers ( infliximab, adalimumab and etanercept). Several molecules are in R&D phase in the prospect of our companies research interests (for more please refer to R&D section).

Specialized in TNF and related tests we offer ELISA kits for the quantitative/qualitative determination of TNF, TNF blockers and anti-TNF blockers

pharmacokinetic studies

 

Researchers can estimate infliximab, etanercept and adalimumab levels in human, mouse, rat and monkey serum samples for pharmacokinetic studies by using relevant Matriks Biotek ELISA kits.

Q-TNF

Enzyme immunoassay for the quantitative determination of Human Tumor Necrosis Factor-alpha (TNF-α) in serum, plasma and cell culture supernatants. The Matriks Biotek sensitive and specific TNF-α determination kit is based on double monoclonal antibody sandwich assay where TNF is captured with one monoclonal antibody on to solid phase and detected by another monoclonal antibody labeled with horse raddish peroxidase. For more information please refer to Instructions for  Use PDF file.

Sample volume: 50 μL                   Total Test Reaction Time: 200 min.

 

 

NEW

Matriks Biotek introduces two new ELISA kits for:

 

1. Enzyme immunoassay for the specific quantitative determination of Infliximab (Remicade®) the first and only ELISA kit in the market for the specific quantitative determination of Infliximab (Remicade®)at uppermost specificity.

2. Enzyme Immunoassay (ELISA) for the Quantification of Human Soluble TNF-RII

 

Q-sTNF-RII

Enzyme Immunoassay (ELISA) for the Quantification of Human Soluble TNF-RII (p75/80 kDa) from Cell Culture Supernatant, Serum, Plasma or Other Body Fluids

Sample volume: 20 μL                    Total Test Reaction Time: 80 min.

 

This immunoassay has been designed to accurately quantitate the recombinant as well as native human soluble TNF-RII (p75/80). Since the measurement of human sTNF-RII by the Human sTNF-RII Immunoassay is insensitive to added TNF and this measurement corresponds to the total amount of the sTNF-RII present in samples, i.e., the total amount of free sTNF-RII plus the total amount of sTNF-RII bound to TNF.

 

 

NEW